J Clin Invest 2014;124:4473-88.ArticlePubMedPMC 58
Extrapolating (modeled estimate), this suggests nearly 29M Americans and 2M Canadians are currently interested in GLP-1 mediations but havent asked their doctor yet
Another natural compound, trigonelline, a methylated form of nicotinic acid, is a newly discovered NAD + precursor able to increase NAD + in multiple species, with preclinical implications for use in sarcopenia, and for muscle and cognitive decline in aging 124,130,131

When to Speak with Your GP About Fertility Concerns Patients using or considering weight loss injections should discuss fertility implications with their GP, particularly in the following circumstances: Planning to conceive within the next 12 months early discussion allows appropriate timing of treatment cessation and optimisation of pre-conception health Experiencing persistent menstrual irregularities beyond the first three months of treatment whilst some cycle changes are expected, prolonged amenorrhoea warrants investigation Existing fertility concerns or previous difficulty conceiving a comprehensive fertility assessment may be needed alongside weight management Considering fertility preservation individuals planning delayed parenthood may wish to discuss options such as egg or sperm freezing Unexplained changes in libido or sexual function though not common, any concerning symptoms should be evaluated Your GP can provide personalised advice based on your individual circumstances, medical history, and reproductive goals
